Study Describes New Models for Testing Parkinson’s Disease Immunotherapies

Using powerful, newly developed cell culture and mouse models of sporadic Parkinson’s disease (PD), a team of researchers from the Perelman School of Medicine at the University of Pennsylvania, has demonstrated that immunotherapy with specifically targeted antibodies may block the development and spread of PD pathology in the brain. By intercepting the distorted and misfolded […]

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New PNAS Paper Describes New Mechanism For B-Cell Selection

Central to our understanding of antibody diversity, B cells hold the key to developing unique and specialized antibodies that selectively bind to specific regions of an antigen.  The key to this specialization is the antigen-binding region that tailors each B cell to a particular antigen and determining whether B cells survive and are selected for […]

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Anti-SOX2 autoantibodies may be immunoprotective response in small cell lung cancer

SOX2 is known as a key stem cell transcription factor involved in the regulation of embryonic development.   SOX2 along with Oct4 and Nanog are a set of factors that are able to reprogram human somatic cells to pluripotent stem cells. In addition to it’s role in stem cells, SOX-2 is over expressed in a […]

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New Anti-PrP mAb As Potential Therapy For Alzheimer’s Disease

Researchers at Trinity College recently published a new study which described the use of a humanized anti-Prion Protein (PrP) antibody with the potential to block the toxic effect of Amyloid Beta (Aβ) protein assemblies believed to play a central role in Alzheimer’s disease (AD)(1). While Aβ interacts with, and likely exhibits its cytotoxic effects through […]

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Mutations in POT1 gene linked to high predisposition for melanoma

While known genetic mutations account for approximately 40 per cent of all occurrences of inherited forms of melanoma there remains a majority of inherited melanomas for which genetic mutations remain to be identified.  In a new study recently published in Nature Genetics (1), researchers set out to identify the hereditary mutations that account for the […]

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