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Figure 4 Regulation of Osx by 2BP.Primary osteoblasts were cultured in differentiation medium with or without 100 M of 2BP for different periods of time. These cells were then collected to isolate total RNA. RT PCR was carried out to determine the mRNA levels of these proteins. The value of control (lane 1) was set at 1.00..

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Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Abstract

Osteoporosis is one of the most common diseases and can be treated by either anti resorption drugs, anabolic drugs, or both. To search for anabolic dr.....
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Leong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Keywords

ALP

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Expression of PATs and protein palmitoylation in osteoblasts...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

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Inhibition of protein palmitoylation compromised p38 MAPK...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

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Inhibition of protein palmitoylation impeded osteoblast differentiation...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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Overexpression of Osx in p53 / osteoblasts rendered resistance to the inhibitory effect of 2BP on differentiation...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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PAT inhibitor decreased BMP2 induced osteoblast differentiation, which was likely mediated by Osx...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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PAT inhibitor show minimal effect on proliferation/survival of osteoblast cultures...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
Highslide JS
Regulation of Osx by 2BP...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details