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Figure 5 Overexpression of Osx in p53 / osteoblasts rendered resistance to the inhibitory effect of 2BP on differentiation.A. 2BP treatment did not significantly down regulate the mRNA levels of Osx. Primary osteoblasts were cultured in the presence or absence of 2BP for different periods of time and total RNA was isolated and RT PCR was carried out to determine the mRNA levels of Osx. The value of control (lane 1) was set at 1.00. B. PAT inhibitor did not markedly affect ALP staining in p53 / osteoblasts. p53 / osteoblasts were treated with different amounts of 2BP for 7 days and then stained for ALP. C. PAT inhibitor did not markedly affect bone nodule formation in p53 / osteoblasts. p53 / osteoblasts were treated with different amounts of 2BP for 21 days and then stained for mineralization..

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Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Abstract

Osteoporosis is one of the most common diseases and can be treated by either anti resorption drugs, anabolic drugs, or both. To search for anabolic dr.....
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Leong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Keywords

ALP

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Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

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Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
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Inhibition of protein palmitoylation impeded osteoblast differentiation...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

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Overexpression of Osx in p53 / osteoblasts rendered resistance to the inhibitory effect of 2BP on differentiation...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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PAT inhibitor decreased BMP2 induced osteoblast differentiation, which was likely mediated by Osx...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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PAT inhibitor show minimal effect on proliferation/survival of osteoblast cultures...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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Regulation of Osx by 2BP...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details