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Figure 6 PAT inhibitor decreased BMP2 induced osteoblast differentiation, which was likely mediated by Osx.A. 2BP diminished the ALP expression induced by BMP2. Primary osteoblasts were cultured in the presence or absence of 2BP for 1 day, and then were further cultured in the presence of 50 ng/ml of BMP2 for 4 days. The plates were then stained for ALP. B. 2BP down regulated BMP2 induced Osx expression. Primary osteoblasts were cultured in the absence or presence of different concentrations of 2BP for a day, and then further cultured in the presence of 50 ng/ml of BMP2 for 16 hrs. The cells were collected and total RNA was isolated, which was used to perform RT PCR to determine the mRNA levels of Osx and Runx2. The value of control (lane 1) was set at 1.00..

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Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Abstract

Osteoporosis is one of the most common diseases and can be treated by either anti resorption drugs, anabolic drugs, or both. To search for anabolic dr.....
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Leong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Keywords

ALP

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Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

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Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
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Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

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Overexpression of Osx in p53 / osteoblasts rendered resistance to the inhibitory effect of 2BP on differentiation...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
Highslide JS
PAT inhibitor decreased BMP2 induced osteoblast differentiation, which was likely mediated by Osx...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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PAT inhibitor show minimal effect on proliferation/survival of osteoblast cultures...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details