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Figure 7 Inhibition of protein palmitoylation compromised p38 MAPK.A. 2BP showed an inhibitory effect on p38 MAPK activation in differentiation assays, without a significant effect on Erk1/2 activation or Smad1/5/8 activation. Primary osteoblasts were cultured in differentiation medium with or without 2BP for different periods of time. Cells were collected for Western blot analysis of the activation of p38, Erk1/2, and Smad1/5/8. B. 2BP also compromised p38 MAPK activation in response to BMP2. Primary osteoblasts were pretreated with PAT inhibitor overnight, and then stimulated with 100 ng/ml of BMP2. Cells were collected at different time points for analysis of p38 and Erk1/2 activation..

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Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Abstract

Osteoporosis is one of the most common diseases and can be treated by either anti resorption drugs, anabolic drugs, or both. To search for anabolic dr.....
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Leong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Keywords

ALP

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Expression of PATs and protein palmitoylation in osteoblasts...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

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Inhibition of protein palmitoylation compromised p38 MAPK...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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Inhibition of protein palmitoylation impeded osteoblast differentiation...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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Overexpression of Osx in p53 / osteoblasts rendered resistance to the inhibitory effect of 2BP on differentiation...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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PAT inhibitor decreased BMP2 induced osteoblast differentiation, which was likely mediated by Osx...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
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PAT inhibitor show minimal effect on proliferation/survival of osteoblast cultures...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details
Highslide JS
Regulation of Osx by 2BP...

Article : Protein Palmitoylation Regulates Osteoblast Differentiation through BMP Induced Osterix Expression
PLoS ONE. 2009 Jan 6; 4(1):e4135

Click to view details