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Figure 7 Projections of the topo I MD motions along the third eigenvector. The two extreme projections and the average protein structure are represented using the same colour scheme of Figure 6. The figure allows the observation of the concerted motion between helix 16, located in core subdomain III, and the C terminal domain. Leu580, the residue with the largest displacement along this eigenvector, is highlighted with a red sphere. Helices 15 and 16, whose motions are uncoupled by the flexibility of the 580 584 loop, are also labelled..

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Protein concerted motions in the DNA human topoisomerase I complex
Nucleic Acids Res. 2003 Mar 1; 31(5):1525-1535

Abstract

The collective motions of the core and C terminal domains of human topoisomerase I (topo I) have been analysed by molecular dynamics simulation of the.....
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Copyright 2003 Oxford University Press



Keywords

1A31

Other images from the same article


Highslide JS
DCC map for the topo I DNA complex...

Article : Protein concerted motions in the DNA human topoisomerase I complex
Nucleic Acids Res. 2003 Mar 1; 31(5):1525-1535

Click to view details
Highslide JS
Displacement of each topo I C atom along the three eigenvectors having the largest eigenvalues...

Article : Protein concerted motions in the DNA human topoisomerase I complex
Nucleic Acids Res. 2003 Mar 1; 31(5):1525-1535

Click to view details
Highslide JS
Order parameter S2 for the (black line) and (red line) dihedral angles of topo I...

Article : Protein concerted motions in the DNA human topoisomerase I complex
Nucleic Acids Res. 2003 Mar 1; 31(5):1525-1535

Click to view details
Highslide JS
Projections of the topo I MD motions along the first eigenvector...

Article : Protein concerted motions in the DNA human topoisomerase I complex
Nucleic Acids Res. 2003 Mar 1; 31(5):1525-1535

Click to view details
Highslide JS
Projections of the topo I MD motions along the third eigenvector...

Article : Protein concerted motions in the DNA human topoisomerase I complex
Nucleic Acids Res. 2003 Mar 1; 31(5):1525-1535

Click to view details
Highslide JS
Ramachandran plots of the topo I DNA complex representing the protein / conformations visited by the MD simulation (black dots)...

Article : Protein concerted motions in the DNA human topoisomerase I complex
Nucleic Acids Res. 2003 Mar 1; 31(5):1525-1535

Click to view details
Highslide JS
Two MD snapshots taken as representatives of the two different families of conformations visited by Glu582 during the simulation...

Article : Protein concerted motions in the DNA human topoisomerase I complex
Nucleic Acids Res. 2003 Mar 1; 31(5):1525-1535

Click to view details