CD68 Human Antibody Review Page
| Entry Name | CD68 HUMAN |
|---|---|
| Full Protein Name | Macrosialin |
| Alternative Names | Gp110, CD68 |
| Gene Name | CD68 |
| Gene Synonym | |
| UniProt ID | P34810 |
| Entrez Gene ID | 968 |
| Ref Seq ID | NM_001251 |
| Functional Description of CD68 | Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Bind to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes, lysosomes to the plasma membrane may allow macrophages to crawl over selectin bearing substrates or other cells. |
| Subcellular Location | Isoform Short: Cell membrane; Single-pass type I membrane protein, Isoform Long: Endosome membrane; Single-pass type I membrane protein, Lysosome membrane; Single-pass type I membrane protein |
| Tissue Specificity | Highly expressed by blood monocytes and tissue macrophages. Also expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. |
| Post Translation Modifications of CD68 | N- and O-glycosylated. |
| Similarity | Belongs to the LAMP family. |
| Mass (Da) | 37408 |
| CD68 Homologs | Human [ P34810 ]Mouse [ P31996 ] |
CD68 Antibody Reviews (Recent papers citing the use of CD68 antibodies)
REPLICATION:
Functional Analysis of Epstein-Barr Virus SM Protein: Identification of Amino Acids Essential for Structure, Transactivation, Splicing Inhibition, and Virion Production
... ...was performed with polyclonal anti-SM antibodies, anti-gp110 monoclonal antibodies (Chemicon), or anti EA-D monoclonal...fixed 48 h after transfection, and stained with anti-gp110 antibody. TABLE 1. In vitro activity, solubility... ...
For checked items above: Link to Article [Free Full Text]
JOURNAL ARTICLE:
Changes in erythropoiesis in hereditary hemochromatosis are not mediated by HFE expression in nucleated red cells
... ...CD68 antibody and non-immune serum (CD68/Con) and of the peripheral blood cells stained with CD68 antibody and with CT16 HFE antibody (CD68/HFE). Below these are the dot plots of fluorescence for the same samples: FL-1 represents FITC fluorescence (CD68 stain-ing... ... Link to Article [Free Full Text]
METABOLISM:
Adipose Tissue Inflammation and Increased Ceramide Content Characterize Subjects With High Liver Fat Content Independent of Obesity
... ...primary antibodies, mouse monoclonal anti-CD68 (Novocastra Laboratories, Newcastle upon Tyne, U.K.), polyclonal guinea pig anti-perilipin (Acris, Hiddenhausen, Germany), or with a mouse monoclonal isotypic control (Abcam, Cambridge, U.K.) for CD68. After rinsing... ... Link to Article [Free Full Text]
ULTRARAPID COMMUNICATIONS:
Transcriptional Repression of ATP-Binding Cassette Transporter A1 Gene in Macrophages: A Novel Atherosclerotic Effect of Angiotensin II
... ...analyses (6% SDS-PAGE; 30 ug protein per lane) using mouse ABCA1 antibody. Sample equivalence was determined by staining Western blot...CD68 antibodies (CD68), anti-MOMA-2 antibodies (MOMA-2), anti-ABCA1 antibodies (ABCA1), or nonspecific antibody (IgG control... ... Link to Article [Free Full Text]
ORIGINAL ARTICLES: CLINICAL NEPHROLOGY:
Histological differences in new-onset IgA nephropathy between children and adults
... ...CD68 antigen (a pan macrophage marker), two-colour immunofluorescence studies were performed on tissue sections using HSn7D2 (anti-Sn; mouse IgG1) and Y1/82A (anti-CD68; mouse IgG2b) as primary antibodies followed by incubation of sections with FITC-conjugated... ... Link to Article [Free Full Text]
