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CLC4A Antibody Review Page

Entry Name CLC4A HUMAN
Full Protein Name C-type lectin domain family 4 member A
Alternative Names C-type lectin superfamily member 6, Dendritic cell immunoreceptor, Lectin-like immunoreceptor, C-type lectin DDB27
Gene Name CLEC4A
Gene Synonym CLECSF6, DCIR, LLIR
UniProt ID Q9UMR7
Entrez Gene ID 50856
Ref Seq ID NM_194450
Functional Description of CLC4A May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
Subcellular Location Membrane; Single-pass type II membrane protein
Tissue Specificity Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha).
Post Translation Modifications of CLC4A
Similarity Contains 1 C-type lectin domain.
Mass (Da) 27512
CLC4A Homologs Human [Q9UMR7]Mouse [Q9QZ15]Rat [Q67EQ0]

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