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CLC4A Antibody Review Page

Entry Name CLC4A HUMAN
Full Protein Name C-type lectin domain family 4 member A
Alternative Names C-type lectin superfamily member 6, Dendritic cell immunoreceptor, Lectin-like immunoreceptor, C-type lectin DDB27
Gene Name CLEC4A
Gene Synonym CLECSF6, DCIR, LLIR
UniProt ID Q9UMR7
Entrez Gene ID 50856
Ref Seq ID NM_194450
Functional Description of CLC4A May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
Subcellular Location Membrane; Single-pass type II membrane protein
Tissue Specificity Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha).
Post Translation Modifications of CLC4A
Similarity Contains 1 C-type lectin domain.
Mass (Da) 27512
CLC4A Homologs Human [Q9UMR7]Mouse [Q9QZ15]Rat [Q67EQ0]

Available CLC4A Antibodies and Other Products

CLC4A Antibody Review Articles (Recent papers citing the use of CLC4A antibodies)

Showing first 5 articles of 13 of articles

BASIC AND TRANSLATIONAL RESEARCH:Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR+ T cells

C Eklöw, D Makrygiannakis, L Bäckdahl, L Padyukov, A-K Ulfgren, J C Lorentzen, and V Malmström
Ann Rheum Dis, Dec 2008; 67: 1742 - 1749.

.... CD4 phycoerythrin (PE), unconjugated anti-DCIR, anti-CD14 PE and anti-CD19 fluorescein...immunohistochemically using mouse monoclonal antibody anti-DCIR MAB1748 (RD Systems, Abingdon, Oxford...using the mouse monoclonal antibodies anti-DCIR 111F8 and anti-CD3 IgG1 (BD Biosciences...

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CUTTING EDGE:Cutting Edge: TREM-Like Transcript-1, a Platelet Immunoreceptor Tyrosine-Based Inhibition Motif Encoding Costimulatory Immunoreceptor that Enhances, Rather than Inhibits, Calcium Signaling via SHP-2

Alexander D. Barrow, Emmanuelle Astoul, Andres Floto, Gary Brooke, Ingrid A. M. Relou, Nicola S. Jennings, Kenneth G. C. Smith, Willem Ouwehand, Richard W. Farndale, Denis R. Alexander, and John Trowsdale
J. Immunol., May 2004; 172: 5838 - 5842.

.... a-granules (Fig. 1 Cii), we found TLT1sp colocalized with CD62P in a-granules when the two images were merged (Fig. 1 Ciii). Anti-TLT1 antisera and anti-CD62P mAb immunostaining revealed that TLT1 was also expressed in a-granules (Fig. 1 Civ). Some TLT1 and...

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BRIEF REVIEWS:Novel Platelet and Vascular Roles for Immunoreceptor Signaling

Frederick F. Samaha and Mark L. Kahn
Arterioscler Thromb Vasc Biol, Dec 2006; 26: 2588 - 2593.

.... bleeding disorder, 61 suggesting that anti-GPVI agents could reduce arterial thrombosis...for 2 weeks after a single injection of anti-GPVI antibodies in mice, 57 the recent development of anti-GPVI antibodies capable of blocking collagen...

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MECHANISMS OF SIGNAL TRANSDUCTION:Phosphorylation and Recruitment of Syk by Immunoreceptor Tyrosine-based Activation Motif-based Phosphorylation of Tamalin

Masayuki Hirose, Jun Kitano, Yoshiaki Nakajima, Koki Moriyoshi, Shigeru Yanagi, Hirohei Yamamura, Takanori Muto, Hisato Jingami, and Shigetada Nakanishi
J. Biol. Chem., Jul 2004; 279: 32308 - 32315.

.... immunoprecipitation of solubilized rat brain P2 membrane fractions with the respective antibodies followed by immunoblotting with anti-mGluR1. As control, preimmune serum or normal IgG was used for immunoprecipitation. The sizes of molecular markers are shown on the...

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DEVELOPMENT/PLASTICITY/REPAIR:Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

Shirley Wakselman, Catherine Béchade, Anne Roumier, Delphine Bernard, Antoine Triller, and Alain Bessis
J. Neurosci., Aug 2008; 28: 8138 - 8143.

.... with primary antibodies (or 48 h for anti-DAP12 antibody) plus Triton X-100 (0.1%) plus gelatin...labeling of neonate hippocampus with anti-DAP12 antibody ( b ) and TREM-2 antibody ( c...Triple labeling of P0 hippocampus with anti-DAP12 antibody ( d ), anti-CD11b antibody ( e...

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CLC4A Antibody Images from Literature

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Overview of the used constructs...
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Hck Src homology 2 (SH2) domain interacts with the phosphorylated immunoreceptor tyrosine based activation motif (ITAM) like sequence of carcinoembryonic antigen related cell adhesion molecule 3 (CEACAM3)...
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Hck Src homology 2 (SH2) domain interacts with the phosphorylated immunoreceptor tyrosine based activation motif (ITAM) like sequence of carcinoembryonic antigen related cell adhesion molecule 3 (CEACAM3) in intact cells...
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Functional analysis...
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Cartoon representation of the Dectin 2 family of C type lectins...
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CLC4A Antibody Publication counts