CP3A4 Antibody Review Page
| Entry Name | CP3A4 HUMAN |
|---|---|
| Full Protein Name | Cytochrome P450 3A4 |
| Alternative Names | Quinine 3-monooxygenase, CYPIIIA4, Nifedipine oxidase, Cytochrome P450 3A3, CYPIIIA3, HLp, Taurochenodeoxycholate 6-alpha-hydroxylase, NF-25, P450-PCN1, Albendazole monooxygenase, Albendazole sulfoxidase |
| Gene Name | CYP3A4 |
| Gene Synonym | CYP3A3 |
| UniProt ID | P08684 |
| Entrez Gene ID | |
| Ref Seq ID | |
| Functional Description of CP3A4 | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. The enzyme also hydroxylates etoposide. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein, Microsome membrane; Single-pass membrane protein |
| Tissue Specificity | Expressed in prostate and liver. |
| Post Translation Modifications of CP3A4 | |
| Similarity | Belongs to the cytochrome P450 family. |
| Mass (Da) | 57343 |
| CP3A4 Homologs | Human [P08684] |
CP3A4 Antibody Review Articles (Recent papers citing the use of CP3A4 antibodies)
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